3-(Hydroxymethyl)phenylboronic acid, also known as (3-(hydroxymethyl)phenyl)boronic acid, is an aromatic boronic acid intermediate identified by CAS 87199-15-3. Its structure combines a boronic acid group with a benzyl alcohol group on a meta-substituted benzene ring, giving buyers two useful chemical handles for synthesis and molecular design. I generally recommend evaluating this material by identity, assay, water content, residual solvents, packaging, and intended reaction performance rather than by price alone.
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The molecular formula is commonly represented as C7H9BO3, with a calculated molecular weight of approximately 151.96 g/mol and one boron atom per molecule. These data are useful for stoichiometric calculations, analytical method development, and procurement documentation. Because physical appearance, purity, hydration state, and stability can vary by manufacturing and packaging conditions, buyers should confirm the current specification and certificate of analysis for each production lot.
This guide is intended for pharmaceutical and fine chemical manufacturers, medicinal chemistry teams, process development laboratories, CROs, CDMOs, and distributors sourcing 3-(Hydroxymethyl)phenylboronic acid. It is especially relevant when the material will be used as a building block for carbon–carbon bond formation or as a multifunctional intermediate in a longer synthetic route. I also recommend this guide to purchasing teams that need to compare technical documents, MOQ, lead time, and supplier responsiveness before placing an order.
The material may be purchased for early research, route scouting, scale-up, or recurring production. Each stage requires a different level of documentation and supply assurance. A small research order may prioritize availability and sample support, while a commercial process normally requires tighter control of impurity profiles, batch consistency, packaging, change notification, and logistics.
3-(Hydroxymethyl)phenylboronic acid contains an aryl boronic acid functionality and a primary alcohol functionality. The aryl boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides, although the practical outcome depends on the catalyst system, base, solvent, temperature, substrate structure, and reaction work-up. The hydroxymethyl group can provide an additional point for derivatization, protection, oxidation, etherification, esterification, or linker construction.
As an aromatic boronic acid, the compound should be treated as a synthesis intermediate rather than as a finished active pharmaceutical ingredient. Its reactivity may be affected by moisture, prolonged storage, repeated container opening, and compatibility with other substances. Buyers should follow the supplier’s storage and handling instructions and should establish their own stability and reaction-performance criteria for the intended application.
| Item | Reference information | Why it matters |
|---|---|---|
| CAS number | 87199-15-3 | Supports identity confirmation and purchasing communication |
| Molecular formula | C7H9BO3 | Used for reaction calculations and analytical records |
| Calculated molecular weight | Approximately 151.96 g/mol | Supports molar conversion and batch planning |
| Functional groups | Aryl boronic acid and primary alcohol | Indicates potential coupling and downstream derivatization options |
The table provides a chemical reference point, not a complete release specification. A commercial specification may additionally include appearance, identification by spectroscopic methods, assay, related substances, water, residual solvents, inorganic residues, and selected elemental impurities. I advise buyers to request a current technical data sheet and lot-specific certificate of analysis before making a quality decision.
The most direct application is use as an aryl boronic acid partner in cross-coupling chemistry. It can be considered when a synthesis requires installation of a substituted biaryl or heteroaryl–aryl motif while retaining or subsequently using the hydroxymethyl group. In discovery chemistry, this combination can help create analogues with different substitution patterns and additional sites for functional modification.
Reaction suitability should be confirmed experimentally because not every boronic acid performs identically across substrates. Possible variables include protodeboronation, oxidation, solubility, catalyst compatibility, and the stability of the alcohol-containing structure under reaction conditions. For this reason, I recommend a small-scale feasibility study before committing to a large purchase for a new route.
The hydroxymethyl group gives the molecule a second functional handle that may be useful in linker or intermediate synthesis. Depending on the route, a chemist may protect the alcohol during coupling, modify it before coupling, or use it in a later transformation. The correct sequence depends on chemoselectivity, protection strategy, purification requirements, and the stability of the boronic acid under the planned conditions.
This multifunctionality can be valuable in pharmaceutical intermediate development, agrochemical research, and specialty organic synthesis. However, multifunctionality may also increase process complexity. Buyers should therefore assess whether the two functional groups support the target route or create additional purification and stability challenges.
At process scale, the key question is not only whether the compound reacts, but whether it can be supplied consistently and handled reproducibly. Important factors include lot-to-lot assay, water content, physical form, impurity profile, filtration behavior, packaging, and availability of repeat batches. A supplier that can provide technical clarification and representative documentation may reduce avoidable delays during route transfer.
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When sourcing this compound, buyers may encounter different grades or documentation packages rather than fundamentally different chemical products. Typical distinctions can include research grade, development grade, and a customized specification for a defined manufacturing process. The chemical identity should remain clear across all options, while acceptance limits and supporting documents may differ.
Do not assume that a listed assay value, appearance, or storage recommendation applies to every supplier or lot. Some suppliers may offer standard packaging, while others can discuss moisture-protective packaging, repacking, or a controlled particle-size approach when technically feasible. Any customization should be confirmed in writing and evaluated against the customer’s analytical and process requirements.
Start with CAS 87199-15-3, chemical name, molecular formula, molecular weight, and the structure required by your route. Confirm whether the material is intended for screening, route development, registration-supporting work, or production. This distinction determines how much documentation, supply continuity, and change control you should request.
Ask for a current specification and a representative certificate of analysis. Key items may include assay method, chromatographic purity, identification data, water content, residual solvents, and relevant elemental impurity information. If your process is sensitive to a particular impurity, communicate that requirement before quotation rather than after delivery.
Discuss the container type, inner liner, labeling, batch traceability, and recommended storage conditions. Boronic acids and alcohol-containing intermediates should be handled according to documented supplier instructions, with attention to moisture exposure and repeated opening. If the material will be stored for an extended period, ask whether stability information or a retest approach is available.
Price should be compared together with pack size, MOQ, lead time, shipping conditions, documentation, and payment terms. A lower unit price may not provide the best total cost if it requires a larger-than-needed commitment or creates schedule risk. MOQ and lead time are product- and batch-dependent, so I recommend requesting a project-specific quotation rather than relying on a general catalog assumption.
Commercial pricing for 3-(Hydroxymethyl)phenylboronic acid can vary with order quantity, purity requirement, packaging, production method, and whether the material is supplied from existing stock or manufactured to order. Research quantities and production quantities should not be evaluated using the same cost model. Buyers should request a tiered quotation that clearly separates product price, packaging, shipping, and any documentation or customization charges.
MOQ may also change according to the requested specification and manufacturing campaign. For a new project, I suggest starting with a sample or small development quantity, followed by a defined scale-up order after reaction and analytical evaluation. Lead time should be confirmed in writing, including sample preparation time, production time, quality release, and transport time.
At Maison Chemical, we support B2B buyers by clarifying product identity, documentation requirements, packaging expectations, and project-specific supply conditions for pharmaceutical intermediates and related fine chemicals. We do not treat one generic specification as suitable for every application. Instead, we encourage customers to share their intended use, target quantity, required documents, and delivery schedule so that we can assess the appropriate supply route.
One common mistake is selecting a supplier solely on catalog price without reviewing the certificate of analysis or impurity requirements. Another is assuming that a boronic acid will perform identically in every coupling system without a route-specific trial. Buyers may also overlook the effect of packaging, storage time, and repeated container opening on material handling and analytical results.
A further risk is failing to distinguish development needs from production needs. A material suitable for exploratory chemistry may not meet the documentation, consistency, or change-control expectations of a regulated manufacturing process. Early communication with the supplier can help identify these differences before they affect procurement or process transfer.
In conclusion, this compound can be a practical building block when your synthesis requires both an aryl boronic acid reaction site and a hydroxymethyl-derived functional handle. The best purchasing decision depends on the complete combination of chemical suitability, analytical quality, supply continuity, and commercial terms. To request a quotation from Maison Chemical, provide the required quantity, target specification, application stage, documentation needs, and delivery location, and we can discuss an appropriate supply solution for your project.
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