2,4-Difluoro-3-methoxybenzoic acid, identified by CAS 178974-97-5, is a fluorinated aromatic carboxylic acid used primarily as a building block in pharmaceutical and medicinal chemistry research. Its structure combines a benzoic acid group with two fluorine substituents at the 2- and 4-positions and a methoxy group at the 3-position. At Maison Chemical, we supply this compound as a pharmaceutical intermediate for customers evaluating synthetic routes, research programs, and scale-up requirements.
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Based on its stated molecular structure, its molecular formula is C8H6F2O3, with a calculated molecular weight of approximately 188.13 g/mol. The molecule contains one carboxylic acid group, two aryl fluorine atoms, and one aromatic methoxy group. These structural features give chemists several points to consider when designing downstream transformations, although the most suitable reaction conditions must be confirmed experimentally for each route.
The main function of 2,4-difluoro-3-methoxybenzoic acid is to serve as a functionalized aromatic starting material. The carboxylic acid group can participate in common medicinal chemistry transformations, including conversion to activated derivatives, amides, esters, or other related intermediates. The fluorine and methoxy substituents remain important features for controlling the identity and properties of the final molecular framework.
In pharmaceutical research, fluorinated aromatic acids are often selected when a project requires a defined substitution pattern rather than an unsubstituted benzoic acid core. Fluorine can influence molecular electronics, lipophilicity, and metabolic behavior, but its final effect depends on the complete structure and should not be assumed from the presence of fluorine alone. The methoxy group can also affect reactivity and polarity, making the exact positional arrangement important for route planning.
The 2,4-difluoro-3-methoxy arrangement is not interchangeable with other difluoromethoxybenzoic acid isomers. Moving a fluorine or methoxy group to another ring position may change steric effects, regioselectivity, reaction behavior, and the properties of later intermediates. For this reason, I recommend that buyers confirm the complete chemical name, CAS number, structure, and specification before placing an order.
2,4-Difluoro-3-methoxybenzoic acid is generally relevant to pharmaceutical intermediate development, medicinal chemistry, and custom synthesis. It may be used as an input for preparing more complex aromatic compounds during discovery or process research. The exact application depends on the customer’s synthetic route, required scale, analytical controls, and downstream product specifications.
This compound should not be confused with a finished active pharmaceutical ingredient. It is an intermediate or research-use building block, and its suitability for a regulated manufacturing process depends on the customer’s own qualification procedures. Before use in a commercial route, buyers should evaluate identity, purity, residual solvents, elemental impurities, water content, and other relevant quality attributes.
For this type of specialty chemical, the most important “material option” is usually the specification package rather than a different grade of the same compound. A research customer may require a small quantity with a basic certificate of analysis, while a process-development customer may need stronger batch-to-batch controls and a more detailed impurity profile. I work with buyers to clarify the intended use before recommending a supply format.
| Item | Reference information | Why it matters |
|---|---|---|
| Product name | 2,4-Difluoro-3-methoxybenzoic acid | Confirms the requested substitution pattern |
| CAS number | 178974-97-5 | Supports identity checking during sourcing |
| Molecular formula | C8H6F2O3 | Provides a structure-based composition reference |
| Calculated molecular weight | Approximately 188.13 g/mol | Useful for reaction calculations and documentation |
Packaging and quantity should be selected according to the project stage. Early research may require only gram-level material, whereas process work may require larger quantities and a more formal supply plan. I do not treat a quoted quantity, purity, or lead time as universal; these details should be confirmed against the current production batch and the buyer’s requested specification.
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Identity is the first specification to confirm, including the product name, CAS number, molecular formula, and analytical characterization. Buyers should also review assay or purity, appearance, water content, residual solvents, and the presence of related substances where those attributes are relevant to the route. A certificate of analysis should clearly identify the batch being supplied and the analytical methods used by the supplier.
For process-development projects, I recommend discussing impurity limits before production begins rather than after delivery. Some customers may need information about trace metals, halides, residual reagents, or specific route-related impurities. These requirements can influence manufacturing, purification, testing, packaging, and final cost.
Where a customer requires additional analytical support, the requested tests should be defined in advance. This helps avoid misunderstandings about whether a standard commercial specification is sufficient or whether a project-specific testing package is needed. Buyers should also confirm whether the material is intended for research, process development, or a regulated manufacturing environment.
When sourcing CAS 178974-97-5, I suggest evaluating more than the initial price. A reliable supplier should be able to communicate product identity, current availability, specification limits, packaging options, and the practical conditions of delivery. For a multi-step pharmaceutical route, consistency and documentation may be more valuable than a small difference in unit price.
Price comparisons should be made on an equivalent basis. Two quotations may differ because of purity, testing scope, packaging, quantity, delivery terms, or whether the material is available from stock or requires production. I recommend requesting a written quotation that separates product price, packaging, testing, shipping, and any project-specific service.
At Maison Chemical, I support buyers who need 2,4-difluoro-3-methoxybenzoic acid for pharmaceutical intermediate and chemical synthesis programs. Our role is to help clarify the requested structure, specification, quantity, packaging, and delivery expectations before the order is finalized. We can also discuss whether a standard specification or a project-specific quality package is more appropriate for the intended use.
For an initial inquiry, please provide the required quantity, target purity or specification, destination country, desired delivery schedule, and any documentation requirements. If you are comparing suppliers, sharing your acceptance criteria allows us to prepare a more relevant quotation instead of offering a generic product description. Availability, MOQ, lead time, and analytical support should be confirmed for each individual inquiry.
2,4-Difluoro-3-methoxybenzoic acid CAS 178974-97-5 is a fluorinated aromatic carboxylic acid used as a pharmaceutical and medicinal chemistry building block. Its key structural features are a carboxylic acid group, two fluorine substituents, and one methoxy substituent in a defined positional arrangement. The calculated molecular formula is C8H6F2O3, and the calculated molecular weight is approximately 188.13 g/mol.
The next step is to match the material specification with your actual synthetic route and quality system. Confirm the CAS number, analytical requirements, quantity, packaging, and documentation before purchase, then review a batch-specific certificate of analysis when available. Contact Maison Chemical with your project requirements so I can help assess supply options for your pharmaceutical intermediate program.
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