2-Fluoro-6-methoxyphenylboronic acid, CAS 78495-63-3, is primarily used as an aromatic boronic acid building block in laboratory research and chemical synthesis. Its boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling reactions, allowing researchers to form a carbon–carbon bond with a suitable aryl or heteroaryl halide. The fluoro and methoxy substituents provide additional structural features for medicinal chemistry, agrochemical research, and the preparation of specialized organic intermediates.
At Maison Chemical, I position this compound as a synthesis intermediate rather than a finished pharmaceutical ingredient, commercial pesticide, or therapeutic substance. Its practical value depends on the target molecule, reaction design, required purity, packaging, and documentation. Buyers should therefore evaluate both the chemical identity and the supplier’s ability to provide consistent, traceable material.
2-Fluoro-6-methoxyphenylboronic acid is an organoboron compound containing an aromatic ring substituted with fluorine, methoxy, and boronic acid groups. The CAS Registry Number is 78495-63-3, and the commonly assigned molecular formula is C7H8BFO3. Its calculated molecular weight is approximately 169.95 g/mol, although the reported value on commercial documentation should always be checked against the product specification and form supplied.
The molecule contains one boronic acid functional group, which is the principal reactive handle used in cross-coupling chemistry. The fluorine atom can influence electronic properties and metabolic stability in downstream molecules, while the methoxy group can alter polarity, steric environment, and biological interaction patterns. These features make the compound useful when a project requires a substituted aryl fragment rather than an unsubstituted phenyl group.
The best-established use of arylboronic acids is cross-coupling with aryl, heteroaryl, or vinyl halides under suitable catalytic and basic conditions. In this context, 2-fluoro-6-methoxyphenylboronic acid acts as the boron-containing partner and transfers its substituted aryl group to the coupling partner. The resulting product can contain a biaryl or aryl–heteroaryl framework that is difficult to obtain efficiently through simple substitution reactions.
Researchers select this building block when they want to introduce both fluorine and methoxy substitution into a larger molecular structure. The exact reaction performance depends on the catalyst, base, solvent, temperature, concentration, substrate compatibility, and work-up method. I therefore recommend treating published reaction conditions as a starting point rather than assuming that one procedure will apply to every substrate.
In pharmaceutical and biotechnology research, this compound may be used to prepare small-molecule analogues for structure–activity relationship studies. A chemist can incorporate the substituted aryl group into a lead structure and then compare changes in potency, selectivity, permeability, solubility, or metabolic behavior. These are research uses, and the boronic acid itself should not be interpreted as an approved active pharmaceutical ingredient.
The combination of a fluoro substituent and a methoxy group is useful for exploring how small changes in aromatic substitution affect a candidate molecule. However, no biological performance should be assumed from the presence of these groups alone. Any activity, safety, or pharmacokinetic conclusion must be established through the buyer’s own validated testing program.
2-Fluoro-6-methoxyphenylboronic acid can also serve as an intermediate in research directed toward crop-protection compounds, plant science chemicals, and other specialty organic molecules. Its role is generally to contribute a defined substituted aryl fragment during multistep synthesis. Whether it is suitable for a particular agrochemical route depends on the final structure, regulatory requirements, impurity profile, and process chemistry.
For route scouting, the compound may be evaluated alongside alternative arylboronic acids, boronate esters, or halogenated anisole derivatives. The preferred option is determined by reaction conversion, selectivity, stability, availability, and downstream purification. A lower-cost material is not automatically the best choice if it creates additional purification or supply risks.
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| Application scenario | Typical role | Important buyer consideration |
|---|---|---|
| Medicinal chemistry | Aryl fragment for analogue and SAR synthesis | Purity, identity confirmation, and batch consistency |
| Agrochemical discovery | Intermediate for substituted aromatic structures | Route compatibility and impurity control |
| Process development | Raw material for reaction optimization and scale-up studies | Lot-to-lot reproducibility and supply continuity |
| Custom synthesis | Building block for a client-defined target molecule | Technical discussion, packaging, and documentation |
Buyers may encounter this chemistry in several related formats, including the free boronic acid, protected boronate esters, or structurally related fluoro- and methoxy-substituted aryl building blocks. The free boronic acid is often selected for direct use in coupling development, while a protected form may be considered when stability, handling, or compatibility with a multistep sequence is important. These materials are not interchangeable without reviewing the reaction and deprotection requirements.
In some synthetic routes, an aryl halide may be used instead of an arylboronic acid. That alternative changes the coupling partner, catalyst requirements, and reaction optimization strategy. I recommend comparing the complete route rather than evaluating the purchase price of a single intermediate in isolation.
For CAS 78495-63-3, the first checks should include the CAS number, chemical name, molecular formula, molecular weight, appearance, assay or purity method, and water content where relevant. A specification should also clarify whether the product is supplied as the intended free acid and whether any stabilizer, solvent, or residual inorganic material is present. The product’s certificate of analysis should correspond to the actual batch supplied.
Because boronic acids can be sensitive to moisture, oxidation, and storage conditions depending on their structure and packaging, buyers should request practical handling information rather than relying only on a catalogue description. A conservative starting point is to keep the material tightly closed, protected from unnecessary moisture and heat, and handled according to the supplier’s safety documentation. Storage temperature, shelf-life, and retest information should be confirmed for the specific lot.
A suitable supplier should be able to confirm chemical identity, provide batch-specific quality documentation, and explain available quantities and packaging. For early discovery work, a small research quantity may be sufficient, while process development requires a stronger focus on repeatability, analytical comparability, and future availability. Buyers should also ask whether the supplier can support repeat orders using the same or an appropriately controlled specification.
Price should be assessed together with purity, lead time, packaging, shipping conditions, and documentation. For example, a material with a nominally attractive price may be less economical if it requires extensive purification or arrives without sufficient analytical information. I encourage procurement and chemistry teams to define their minimum acceptance criteria before requesting quotations.
Maison Chemical supplies organic boronic acid building blocks for research, development, and industrial sourcing programs. For 2-fluoro-6-methoxyphenylboronic acid CAS 78495-63-3, I can support buyers with product identification, specification discussions, quotation preparation, packaging coordination, and export-oriented order communication. Availability, quantity, lead time, and documentation should be confirmed for each inquiry because they may vary by production schedule and order requirements.
Our practical approach is to match the material to the buyer’s intended use rather than make unsupported performance claims. If your team is developing a Suzuki coupling route, screening substituted aromatic fragments, or planning repeat procurement, provide the desired quantity, purity target, destination, and documentation requirements. This information allows us to prepare a more relevant commercial response.
2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3 is used mainly to build more complex aromatic molecules, especially through Suzuki–Miyaura coupling. It supports medicinal chemistry, agrochemical discovery, process development, and custom synthesis when a fluoro- and methoxy-substituted aryl unit is required. Its suitability depends on the target route and the buyer’s quality requirements, so application-specific evaluation remains essential.
The next practical step is to compare the required reaction, purity, quantity, packaging, and documentation with the supplier’s specification. Contact Maison Chemical with your target quantity, intended application, destination, and preferred quality criteria to request current availability and a B2B quotation for CAS 78495-63-3.
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