3-Fluoro-2-methylbenzeneboronic acid, identified by CAS 163517-61-1, is an aromatic boronic acid used primarily as a synthetic building block in organic and medicinal chemistry. Its structure combines a fluorinated methyl-substituted benzene ring with a boronic acid group, allowing it to participate in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. The listed molecular formula is commonly represented as C7H8BFO2, with a calculated molecular weight of approximately 153.95 g/mol. At Maison Chemical, I position this product for research, process-development, and commercial sourcing programs that require controlled identity, documentation, and dependable supply coordination.
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3-Fluoro-2-methylbenzeneboronic acid belongs to the family of aryl boronic acids. The boronic acid functionality is the key reactive site, while the fluoro and methyl substituents influence the electronic and steric characteristics of the aromatic ring. These features can affect coupling behavior, reaction optimization, purification, and the properties of the final intermediate.
| Property | Information |
|---|---|
| Product name | 3-Fluoro-2-methylbenzeneboronic acid |
| CAS number | 163517-61-1 |
| Common chemical formula | C7H8BFO2 |
| Approximate molecular weight | 153.95 g/mol |
| Functional group | Aryl boronic acid |
The molecular weight provides a useful reference for laboratory calculations. For example, 1.00 mmol corresponds to approximately 153.95 mg before accounting for assay, moisture, or any form-related correction. Similarly, 10.00 mmol corresponds to approximately 1.5395 g on a theoretical 100% purity basis. I recommend that customers use the actual certificate of analysis when adjusting weighing calculations for production or validated procedures.
The principal role of this compound is to provide an aryl fragment for carbon–carbon bond formation. In a typical Suzuki–Miyaura process, the boronic acid reacts with an aryl or heteroaryl halide in the presence of a suitable palladium catalyst, base, and solvent system. The reaction can create biaryl structures that are frequently found in pharmaceutical intermediates, agrochemical research compounds, and advanced material molecules.
The fluoro substituent remains part of the coupled product when the boronic acid group is replaced by a new carbon–carbon bond. This retained fluorine can be valuable for tuning molecular polarity, metabolic behavior, lipophilicity, or downstream functionalization. The methyl group also remains on the aromatic ring and may contribute to steric or electronic control in the target structure.
Beyond a single coupling reaction, the compound may serve as a defined aromatic building block in multi-step synthesis. Its value depends on the target molecule, the selected reaction partners, and the compatibility of the fluoro and methyl substituents with later transformations. I therefore recommend evaluating it as part of the complete route rather than judging suitability only from the product name.
Researchers may select CAS 163517-61-1 when they need a substituted aryl boronic acid for discovery chemistry or route development. Common project areas can include pharmaceutical intermediate synthesis, medicinal chemistry libraries, agrochemical research, and the preparation of functional aromatic molecules. The exact application should be confirmed against the customer’s reaction conditions and quality requirements.
In process chemistry, buyers typically need more than a catalog identity. They may require batch-to-batch consistency, impurity information, residual solvent data, elemental analysis, and packaging that supports safe transfer into a controlled production environment. Maison Chemical can discuss these requirements before quotation so the proposed grade and documentation match the intended use.
For early-stage screening, a customer may prioritize availability, small quantities, and a practical certificate of analysis. The material should still be identified by CAS number, chemical name, lot number, assay or purity result, and storage guidance. A research-grade purchase is appropriate only when the project does not yet require validated manufacturing controls.
For scale-up, I recommend a more detailed specification review. Important points may include assay method, water content, residual solvents, related substances, inorganic residues, physical description, packaging configuration, and retest or re-evaluation information. The final specification should be agreed before order placement because acceptable limits can vary by route and customer quality system.
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Purity should never be assumed from a generic online listing. For example, a stated value such as 98% is meaningful only when the analytical method, basis of calculation, and lot-specific result are provided. Maison Chemical can review the requested purity range and confirm which documents are available for the specific batch.
As with other boronic acids and fine chemicals, the product should be handled according to its current safety data sheet and applicable site procedures. Personnel should use suitable protective equipment, avoid unnecessary dust generation, and verify compatibility with the selected solvent and reaction system. I do not recommend assigning a fixed storage temperature, shelf life, or stability period without batch-specific supplier guidance and supporting data.
Buyers should also consider that boronic acids can require careful control of moisture, temperature, and container closure during storage. The appropriate conditions depend on the material form, packaging, local climate, and supplier stability information. Before opening a commercial package, the receiving laboratory should confirm the label, lot number, net weight, CoA, SDS, and any handling instructions.
The supplier should clearly connect the product name, CAS 163517-61-1, formula, molecular weight, lot number, and analytical documentation. I recommend requesting a representative or lot-specific CoA before final approval, especially when the material will enter a regulated or quality-controlled workflow. The SDS should also be available for hazard communication and internal risk assessment.
Supplier evaluation should include available quantity, minimum order quantity, production or dispatch lead time, packaging, export documentation, and shipping constraints. A low unit price may not represent the lowest total sourcing cost if documentation, repacking, customs support, or delivery reliability are inadequate. Buyers should compare quotations on an equivalent specification and delivery basis.
A responsive supplier can help identify missing information before it becomes a purchasing problem. I encourage customers to share the intended application, estimated annual demand, required assay, destination country, and any special documentation needs. This allows Maison Chemical to provide a more practical quotation instead of a generic price response.
Maison Chemical supplies 3-Fluoro-2-methylbenzeneboronic acid for customers evaluating laboratory, development, and commercial requirements. I can support product identification, specification alignment, CoA and SDS document review, packaging discussions, export coordination, and quotation preparation. Availability and lead time depend on the required quantity, grade, batch status, and destination.
For larger or recurring programs, I recommend discussing forecast demand and delivery timing in advance. This can help align production planning, documentation review, and shipment scheduling. Any statement regarding purity, quantity, lead time, or storage should be confirmed against the current batch and commercial offer rather than treated as a universal product guarantee.
3-Fluoro-2-methylbenzeneboronic acid CAS 163517-61-1 is a specialized aromatic coupling building block rather than a finished-use chemical. Its practical value comes from combining a reactive boronic acid group with a fluoro-methyl substituted ring, making it relevant to the preparation of diverse aromatic intermediates. The correct purchasing decision depends on confirmed identity, fit-for-purpose specifications, documentation, and dependable delivery support.
To evaluate this material for your project, prepare the required quantity, target purity, application, destination, packaging preference, and documentation list. Contact Maison Chemical with these details so I can help review the appropriate supply option and provide a current quotation based on your actual requirements.
Contact us to discuss your requirements of 3-Fluoro-2-methylbenzeneboronic acid CAS 163517-61-1. Our experienced sales team can help you identify the options that best suit your needs.
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