I supply 2,4,6-trifluorophenylboronic acid, CAS 182482-25-3, as a specialty organic boronic acid for research, medicinal chemistry, and process-development applications. The compound is generally identified by the molecular formula C6H4BF3O2 and a calculated molecular weight of approximately 175.90 g/mol. Its primary synthetic value is the aryl boronic acid functional group, which can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling to form substituted biaryl structures. For bulk purchasing, I recommend confirming identity, assay, water content, residual solvents, packaging, and batch documentation before placing a production order.
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This guide is intended for pharmaceutical and agrochemical research teams, contract development and manufacturing organizations, fine-chemical distributors, university laboratories, and procurement specialists sourcing specialty building blocks. It is also relevant to process chemists who need to move from milligram-scale screening toward gram- or kilogram-scale preparation. I focus here on practical purchasing and technical evaluation rather than presenting an unverified product specification sheet.
Because commercial specifications can differ by supplier and batch, I distinguish between publicly reported identity information and specifications that must be confirmed by a current certificate of analysis. This approach helps buyers avoid treating catalog descriptions as guaranteed production specifications. It also gives procurement and quality teams a clear list of questions to send to a supplier before approval.
2,4,6-Trifluorophenylboronic acid is an aryl boronic acid in which a boronic acid group is attached to a benzene ring bearing fluorine substituents at the 2, 4, and 6 positions. The “2,4,6-trifluoro” substitution pattern describes the location of the three fluorine atoms relative to the boronic acid-bearing carbon. The boronic acid group provides a reactive handle for forming new carbon–carbon bonds under suitable coupling conditions.
Public chemical databases identify the material by CAS RN 182482-25-3 and associate it with the molecular formula C6H4BF3O2. Based on that formula, the approximate molecular weight is 175.90 g/mol, and one mole contains one boron atom, three fluorine atoms, two oxygen atoms, six carbon atoms, and four hydrogen atoms. I recommend using a current supplier specification and analytical data to confirm the identity of the specific lot being purchased.
Authoritative reference: PubChem provides chemical identity and structure information for many boronic acid building blocks, while the International Union of Pure and Applied Chemistry explains standard chemical nomenclature and molecular representation principles. Buyers can consult the relevant PubChem record and supplier documentation together rather than relying on a single database entry.
The molecular weight is useful when converting a mass-based order into molar quantity for reaction planning. At 175.90 g/mol, 100 g of material corresponds to approximately 0.568 mol before accounting for assay, water, or other impurities. Similarly, 1.000 kg corresponds to approximately 5.685 mol on a nominal 100% basis.
These calculations are planning values, not an assay result. If a batch has an assay of 98.0%, the effective amount of principal compound will be lower than the nominal mass, and the final calculation should also consider the reported basis of the assay. I recommend asking whether the supplier reports assay on an as-is basis, dried basis, or another defined basis.
| Item | Reference value or planning figure | Procurement relevance |
|---|---|---|
| CAS RN | 182482-25-3 | Primary identity cross-reference |
| Molecular formula | C6H4BF3O2 | Structure and composition check |
| Approximate molecular weight | 175.90 g/mol | Mole-to-mass conversion |
| Nominal amount in a 100 g order | Approximately 0.568 mol | Reaction and inventory planning |
| Nominal amount in a 1.000 kg order | Approximately 5.685 mol | Scale-up and production planning |
The most relevant use of this compound is as an aryl boronic acid coupling partner. In a suitable Suzuki–Miyaura reaction, the aryl boronic acid can react with an aryl or heteroaryl halide to create a biaryl or related carbon–carbon bond. The exact reaction outcome depends on the coupling partner, catalyst, base, solvent, temperature, reaction time, and sensitivity of the substrate.
The fluorine substituents can be valuable when a project requires a fluorinated aromatic motif. However, the presence of fluorine does not guarantee a particular biological, physical, or formulation performance in a final molecule. I therefore recommend evaluating the compound as a synthetic intermediate and assessing the final product separately through the customer’s own development and analytical program.
The Suzuki–Miyaura reaction was established as a major method for palladium-catalyzed carbon–carbon bond formation in the published work of Suzuki and co-workers. A frequently cited review by Miyaura and Suzuki describes the reaction scope and mechanistic background. That literature supports the general application category, but it does not establish a universal process for every substrate or manufacturing route.
Medicinal chemistry teams may use 2,4,6-trifluorophenylboronic acid to introduce a fluorinated aryl fragment during analog synthesis. Agrochemical discovery programs may evaluate related fluorinated building blocks when modifying molecular properties during lead optimization. In both cases, its usefulness is project-specific and should be judged by reaction performance, impurity control, and downstream purification requirements.
For route development, the buyer should compare this material with alternative fluorinated aryl halides or other boronic acid derivatives. The best choice may depend on the availability of the complementary coupling partner, catalyst compatibility, waste profile, isolation method, and the stability of the intermediate. A lower purchase price does not necessarily produce a lower total process cost if the material creates additional purification or rework requirements.
Suppliers may offer this compound in different quality categories, such as research grade, high-assay synthesis grade, or a customer-defined process grade. These labels are not interchangeable unless the supplier clearly defines the acceptance criteria. I recommend requesting the actual specification document instead of selecting a product solely from a grade name.
Important specification items may include appearance, identification by techniques such as NMR or mass spectrometry, assay, related substances, water content, residual solvents, inorganic residues, and packaging conditions. Depending on the buyer’s quality system, the documentation package may also include a certificate of analysis, safety data sheet, batch traceability information, and a statement regarding applicable regulatory or restricted-substance requirements.
| Specification area | What I recommend confirming |
|---|---|
| Identity | CAS RN, molecular formula, structure, and analytical identification method |
| Assay | Acceptance limit and whether the result is reported on an as-is or dried basis |
| Impurities | Related substances, regioisomers, starting materials, and inorganic residues |
| Water | Testing method and maximum limit, especially for moisture-sensitive processes |
| Physical form | Powder or solid form, color range, particle characteristics, and handling requirements |
| Packaging | Container material, inner liner, seal integrity, label information, and pack size |
Organic boronic acids can require controlled storage and careful handling, but the appropriate conditions depend on the supplier’s stability information and the customer’s internal procedures. I do not recommend assigning a fixed temperature or shelf life without product-specific evidence. Instead, buyers should request the recommended storage range, retest period, stability statement, and any light, moisture, or atmosphere precautions from the supplier.
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For laboratory purchasing, a 1 g or 5 g pack may be suitable for initial feasibility work, while 25 g, 100 g, or kilogram-scale quantities may be more relevant to route development. These quantities are common planning points rather than a guaranteed Maison Chemical pack-size list. I confirm available packaging and minimum order quantity against the current production or inventory position before quotation.
First, I ask whether the material is intended for reaction screening, medicinal chemistry, process development, analytical reference work, or commercial manufacturing. Each use can require a different balance between assay, impurity profile, documentation, and price. A screening laboratory may prioritize availability and small-pack flexibility, while a manufacturing customer may require tighter impurity limits and change-control support.
Next, the buyer should identify the attributes that could affect the reaction or downstream purification. These may include assay, water, residual solvents, palladium or other metal residues, related aryl impurities, and physical handling characteristics. I recommend separating mandatory acceptance criteria from preferred targets so that the supplier can evaluate technical feasibility without creating unnecessary cost.
A current certificate of analysis should correspond to the quoted batch or to a representative production lot. I recommend checking the test methods, reporting units, acceptance limits, and whether chromatographic purity is equivalent to assay; these terms can describe different measurements. For a new supplier, a pre-shipment sample or a small qualification order can reduce the risk of discovering an unexpected impurity profile after a larger purchase.
Bulk supply discussions should include the requested quantity in grams or kilograms, target delivery date, preferred packaging, destination, and whether repeat orders are expected. A supplier may have a different lead time for stocked material, campaign production, and custom specification material. I also recommend asking how the supplier manages batch-to-batch consistency, raw-material changes, and notification of major process changes.
The price of 2,4,6-trifluorophenylboronic acid can vary with assay, quantity, packaging, production route, inventory status, analytical requirements, and shipping destination. A quotation without a defined specification can be difficult to compare because one supplier may include more testing or documentation than another. I provide the most useful quotation when the buyer specifies the target quantity, grade, required documents, delivery location, and whether a sample approval step is needed.
Minimum order quantity is often connected to the supplier’s available stock and production economics. For example, a small research pack and a 1 kg production order may follow different packaging, testing, and scheduling procedures. I recommend requesting separate pricing for the immediate requirement and the expected annual volume when the project may scale.
Lead time should be stated as an estimated business-day or calendar-day range only after confirming stock status and release requirements. Buyers should also ask whether the quoted lead time includes quality-control release, export documentation, and transport. Where timing is critical, I suggest agreeing on a sample-approval milestone and a final batch-release document list before issuing a purchase order.
For international sourcing, I also recommend checking the classification and documentation requirements applicable to the destination country. The Globally Harmonized System provides an internationally recognized framework for communicating chemical hazards through labels and safety data sheets, but the final classification and transport requirements may depend on the jurisdiction and product-specific assessment. I use the current safety data sheet and shipment information as the practical basis for documentation review.
One common mistake is assuming that a high chromatographic purity number automatically confirms suitability for every reaction. Water, residual solvents, trace metals, and specific regioisomeric impurities may be more relevant to a particular process than a single purity value. A second mistake is failing to define whether the required quantity is nominal material mass or active-compound equivalent.
Another mistake is comparing prices without comparing the scope of testing and documentation. A low price may exclude a customer-specific impurity panel, sample testing, special packaging, or batch reservation. I recommend evaluating the total delivered cost, qualification effort, expected yield impact, and supply risk rather than unit price alone.
At Maison Chemical, I support buyers by first clarifying the intended application and required quantity. I can then help organize a request covering identity, assay, impurity expectations, packaging, analytical documents, and delivery requirements. This specification-first approach is useful when a customer needs to compare suppliers or transfer a laboratory procedure toward a larger scale.
Depending on the project and available batch status, supplier support may include product information, a current certificate of analysis, safety documentation, quotation preparation, packaging coordination, and shipment planning. Any exact specification, stock position, lead time, or price should be confirmed in a written quotation because these details can change by batch and destination. I do not recommend treating general catalog information as a substitute for a project-specific quality review.
2,4,6-Trifluorophenylboronic acid CAS 182482-25-3 is a fluorinated aryl boronic acid used primarily as a building block for carbon–carbon bond formation, especially Suzuki–Miyaura coupling. Its publicly reported identity includes the formula C6H4BF3O2 and an approximate molecular weight of 175.90 g/mol. The correct bulk specification depends on the reaction, impurity sensitivity, documentation requirements, quantity, and delivery schedule.
My recommended next step is to prepare a concise sourcing brief stating the required mass, target assay, impurity limits, water or residual-solvent requirements, packaging, documents, destination, and desired delivery date. Maison Chemical can then review the request and provide a project-specific quotation or clarify which requirements need further technical confirmation. This process gives procurement, quality, and chemistry teams a more reliable basis for approving the material.
Request a supply review from Maison Chemical: Send your target quantity, application, specification requirements, packaging preference, and delivery location so I can help assess the appropriate supply option for 2,4,6-trifluorophenylboronic acid.
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