3,5-Dichlorophenylboronic acid, CAS 67492-50-6, is an aromatic boronic acid used mainly as a building block in organic synthesis. Its molecular formula is C6H5BCl2O2, and its calculated molecular weight is approximately 190.82 g/mol. The molecule contains a phenyl ring, two chlorine substituents at the 3- and 5-positions, and a boronic acid group that can participate in carbon–carbon bond-forming reactions. I typically position this material for medicinal chemistry, agrochemical research, pharmaceutical intermediate development, and other laboratory-scale or process-development applications where a 3,5-dichlorophenyl group is required.
You can find more information on our web, so please take a look.
Because appearance, assay, water content, residual solvents, and storage requirements can vary by production route and supplier specification, I recommend confirming the current certificate of analysis and safety data sheet before purchasing. The identity information below is suitable for initial material screening, while project release should rely on batch-specific documentation.
CAS 67492-50-6 identifies 3,5-dichlorophenylboronic acid as a substituted aryl boronic acid. The compound has one boronic acid group, represented by –B(OH)2, attached to an aromatic ring containing two chlorine atoms. The 3,5-substitution pattern places the chlorine atoms symmetrically relative to the boronic acid-bearing carbon, which can influence steric and electronic behavior during synthesis.
| Identifier or characteristic | Information |
|---|---|
| Common name | 3,5-Dichlorophenylboronic acid |
| CAS number | 67492-50-6 |
| Molecular formula | C6H5BCl2O2 |
| Calculated molecular weight | Approximately 190.82 g/mol |
| Halogen content | Two chlorine atoms per molecule |
| Reactive functional group | Aryl boronic acid, –B(OH)2 |
The formula and molecular-weight value are calculated from the elemental composition and should not be confused with a batch test result. I use these values for procurement checks, reaction calculations, and preliminary formulation or analytical planning. For an authoritative chemical identity record, buyers can consult the National Center for Biotechnology Information PubChem database and compare the supplier’s specification with the relevant compound record.
Source: National Center for Biotechnology Information, PubChem.
Aryl boronic acids are widely used as partners in palladium-catalyzed Suzuki–Miyaura coupling, in which an aryl or heteroaryl boronic acid reacts with a suitable halide or related electrophile to form a carbon–carbon bond. This reaction family is valuable because it can connect the 3,5-dichlorophenyl fragment to diverse aromatic, heteroaromatic, and other sp2-carbon frameworks. The exact reaction yield and selectivity depend on the coupling partner, catalyst, base, solvent, temperature, concentration, and work-up procedure.
The two chlorine atoms are not simply passive mass contributors. They remain available as substituents in the coupled product and may affect lipophilicity, steric profile, metabolic behavior, and downstream functionalization strategy. However, I do not recommend predicting final biological or performance properties from the starting material alone; those conclusions require compound-specific testing.
The primary function of 3,5-dichlorophenylboronic acid is to provide a substituted aryl fragment during synthetic route development. In a typical Suzuki–Miyaura sequence, the boronic acid group is consumed while the aryl carbon forms a new bond with a coupling partner. Chemists may therefore use this material to prepare biaryl, aryl-heteroaryl, or related substituted aromatic intermediates.
Reaction development should account for possible boronic acid protodeboronation, sensitivity to aqueous or strongly basic conditions, and compatibility with the selected catalyst system. I recommend screening a small number of bases and solvent systems rather than assuming that one general coupling protocol will apply to every substrate. The final process should be validated using reaction-specific analytical data such as HPLC, LC–MS, GC where appropriate, and NMR.
In medicinal chemistry, this compound can serve as a modular aromatic input for generating analogues with a 3,5-dichlorophenyl motif. The boronic acid functionality allows researchers to vary the second coupling partner while keeping the substituted phenyl portion constant. This modularity can support structure–activity relationship studies, although any pharmacological activity, toxicity profile, or clinical relevance belongs to the final molecule and cannot be assigned to the starting material without evidence.
The same synthetic flexibility can be relevant to agrochemical discovery, fine-chemical development, and specialty intermediate production. Buyers may select this compound when the target structure requires both a boron-mediated coupling handle and a dichlorinated aromatic ring. I suggest confirming whether the project needs research-grade material, a higher-purity process input, or a custom specification before requesting a quotation.
Source: The Royal Society of Chemistry provides background information on boronic acids and their role in organic synthesis through its chemical information resources. Reaction conditions remain substrate-dependent and should be supported by project-specific laboratory data.
The most reliable starting parameters for procurement are the CAS number, formula, molecular weight, substitution pattern, and requested purity. Buyers should not assume that a catalogue description alone establishes melting point, color, particle size, water content, or stability period. Those values should be taken from the current technical data sheet, certificate of analysis, or validated supplier specification for the exact batch.
For laboratory handling, I recommend using the supplier’s SDS as the controlling document. Work should be performed by trained personnel with appropriate ventilation, protective gloves, eye protection, and procedures for managing chemical dust or accidental exposure. Storage temperature, light protection, container closure, and moisture controls should be selected according to the current SDS and stability information rather than copied from a generic boronic-acid guideline.
You will get efficient and thoughtful service from Maison Chemical.
A practical incoming inspection may include visual examination, identity confirmation, assay or purity testing, and review of water and residual-solvent data where relevant to the process. Depending on the application, laboratories may use NMR, LC–MS, HPLC, elemental analysis, or other validated methods. I recommend defining acceptance criteria before ordering so that the supplier can quote against a clear specification instead of an ambiguous “high-purity” request.
For regulated or scale-up work, traceability is particularly important. The purchasing file should normally include the product name, CAS number, lot number, manufacturing or retest information where supplied, certificate of analysis, SDS, packaging details, and transport documentation when applicable. These documents help distinguish a verified batch from an unqualified marketplace listing.
Source: The United Nations Globally Harmonized System of Classification and Labelling of Chemicals explains the purpose of SDS and hazard communication. Buyers can review the current framework through the United Nations Economic Commission for Europe GHS resources.
Suppliers may offer different purity levels for research, process development, or manufacturing use. A higher stated assay may be important for a sensitive coupling route, but the best choice also depends on impurity identity, water content, packaging, and the customer’s analytical method. I recommend evaluating the complete specification rather than selecting only by the headline purity percentage.
Packaging can range from small laboratory quantities measured in grams to larger project quantities measured in kilograms. The suitable pack size depends on expected consumption, shelf-life planning, handling controls, and whether the material is needed for route screening or repeated production campaigns. For an initial project, a smaller qualification quantity can reduce the risk of committing to a large batch before the chemistry is confirmed.
Some buyers require additional documentation, controlled labeling, specific inner packaging, or a defined lot size. These requirements should be stated before quotation because they can affect production scheduling and final cost. I can review the requested specification and identify which items are standard supply information and which may require a technical or quality assessment.
I recommend beginning with a document-based qualification. Confirm that the supplier can provide a consistent CAS reference, molecular formula, current SDS, certificate of analysis, analytical method or test summary, and clear batch identification. If the compound will enter a validated process, also ask whether the supplier can support change notification, retained samples, and agreed release specifications.
Request a quotation that states quantity, purity, packaging, Incoterms, lead time, payment terms, and document availability. Lead time should be treated as an estimate until production capacity and raw-material availability are confirmed. Buyers should also clarify whether the quoted material is in stock, made to order, or subject to a new synthesis campaign.
Price alone is not a sufficient comparison point for a specialty intermediate. A lower unit price may be offset by a larger minimum order quantity, insufficient documentation, longer release time, or a specification that does not match the intended reaction. I suggest comparing landed cost, usable assay, delivery risk, and technical support together.
At Maison Chemical, I approach 3,5-dichlorophenylboronic acid as a technical sourcing requirement rather than a simple catalogue transaction. I can help customers review the target specification, required quantity, analytical documentation, packaging expectations, and delivery schedule before a quotation is prepared. This approach is intended to reduce avoidable mismatches between the material ordered and the material needed for the customer’s synthetic route.
Our support can be structured around laboratory screening, process development, recurring intermediate supply, or a larger custom requirement, subject to technical review and production feasibility. I do not treat a general product description as a substitute for a batch-specific certificate or SDS. Instead, I encourage buyers to confirm the acceptance criteria, documentation package, and logistics plan in writing.
3,5-Dichlorophenylboronic acid CAS 67492-50-6 is generally considered a useful research and process-development building block when a synthetic route requires a 3,5-dichlorophenyl fragment and a boronic acid coupling handle. Its known identity parameters include the CAS number 67492-50-6, formula C6H5BCl2O2, and calculated molecular weight of approximately 190.82 g/mol. The appropriate grade depends on the reaction, analytical acceptance criteria, scale, and documentation requirements.
As a next step, I recommend preparing an RFQ that states the required quantity, target purity, packaging, delivery location, documentation, and intended application. Maison Chemical can then review the requirement and provide supplier-side information subject to availability and technical confirmation. Contact us with your specification to discuss a suitable supply route for 3,5-dichlorophenylboronic acid.
Are you interested in learning more about 3,5-Dichlorophenylboronic acid CAS 67492-50-6? Contact us today to secure an expert consultation!
Comments
Please Join Us to post.
0